Abstract Only
Clinical Trial
Can vitamin D supplements slow aging at the cellular level by protecting telomeres?
Original title: Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
Haidong Zhu, JoAnn E. Manson, Nancy R. Cook +8 moreAmerican Journal of Clinical Nutrition2025-05-21DOI
Sample Size
1,054 participants
Study Type
Clinical Trial
Duration
5 years for parent VITAL trial; 4 years of follow-up for LTL measurements (baseline, Year 2, Year 4)
Overview
In Plain Language
Daily vitamin D3 supplements reduced telomere shortening by about 140 base pairs over 4 years, suggesting potential anti-aging benefits.
Clinical trial1,054 participants
The Numbers
Absolute risk: Not applicable - continuous outcome (telomere length in kilobase pairs)
Relative risk (Not applicable -):
- Vitamin D3 reduced telomere attrition by 0.14 kb (140 bp) over 4 years; 0.035 kb higher per year of follow-up
Important caveat: Not mentioned in provided text